N-acetyltransferase 2 (arylamine N-acetyltransferase), also known as NAT2, is an
enzyme which in humans is encoded by the ''NAT2''
gene.
Function
This gene encodes a type of
N-acetyltransferase N-acetyltransferase (NAT) is an enzyme that catalysis, catalyzes the transfer of acetyl groups from acetyl-CoA to arylamines, arylhydroxylamines and arylhydrazines. They have wide specificity for aromatic amines, particularly serotonin, and can also ...
. The NAT2
isozyme functions to both activate and deactivate arylamine and
hydrazine
Hydrazine is an inorganic compound with the chemical formula . It is a simple pnictogen hydride, and is a colourless flammable liquid with an ammonia-like odour. Hydrazine is highly toxic unless handled in solution as, for example, hydrazine ...
drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow
acetylator phenotypes. Polymorphisms in NAT2 are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (
NAT1) is located near NAT2.
Phenotype prediction
The NAT2 acetylator phenotype can be inferred from NAT2 genotype (a combination of
SNPs observed in a given individual).
References
Further reading
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External links
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The Arylamine N-acetyltransferase Gene Nomenclature Committee homepagePDBe-KBprovides an overview of all the structure information available in the PDB for Human Arylamine N-acetyltransferase 2
Human proteins
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